Combination Antidepressant Treatment Outperforms Monotherapy in Meta-Analysis

"In clinical management of depression, combining a reuptake inhibitor with presynaptic alpha2-autoreceptors significantly improves treatment outcomes, compared with monotherapy, a meta-analysis found. Clinicians should consider this approach as a viable first-line treatment for severe depression and for nonresponders, a team of German researchers concluded."

https://www.medscape.com/viewarticle/968659?spon=12&uac=392623PN&impID=4038426&sso=true&faf=1&src=WNL_mdpls_220222_mscpedit_psych